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KMID : 1134819990280020452
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 2 p.452 ~ p.457
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Antimutagenic Effect of the Fruiting Body and the Mycelia Extracts of Coprinus comatus
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Kim Hyun-Jeong
Lee Byeung-Hun
Kim Og-Mi
Bae Jun-Tae
Park Sun-Hee
Park Dong-Chul
Lee Kap-Rang
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Abstract
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The inhibitory effect of Coprinus comatus on the mutagenicity in Salmonella assay system and SOS chromotest were studied. In Ames test, the ethanol and water extracts and the cultured mycelia fractions of Coprinus comatus did not show any mutagenicity, but the Coprinus comatus ethanol extracts showed inhibitory effects of 80~90% on the mutagenicity induced by indirect mutagen of benzo(a)pyrene(B(a)P) and aflatoxin B₁(AFB₁) in Salmonella typhimurium TA98 and TA100. The antimutagenic effect increased with increasing concentration of the ethanol extract toward N-methyl-N′-nitro-N-nitrosoguanidine(MNNG). However, the water extracts inhibited about 40~50% against direct and indirect mutagen. The cultured mycelial filtrate of Coprinus comatus, the fraction Ⅱ, showed antimutagenic effect of 90% on MNNG and 25~50% on B(a)P and AFB₁. In SOS chromotest, the ethanol extracts of Coprinus comatus showed antimutagenic effect of 65~81% on SOS function induced by 4-NQO, and the cultured mycelia fraction Ⅱ showed low inhibitory effect of 20~50%.
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KEYWORD
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Coprinus comatus, Salmonella assay, SOS chromotest, antimutagenicity
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